6-amino-7-deaza-purine derivatives, a process for its preparation and its use as kinase inhibitors

摘要

A compound of formula (I) ** Formula ** characterized in that R1 is hydrogen, methyl, cyclopropyl or COR6, where R6 is methyl; R2 is hydrogen or an optionally substituted group selected from linear or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, aryl, heteroaryl, a 3- to 4- or 6- to 7-membered heterocyclyl ring, where one or more atoms Carbon atoms are replaced by nitrogen, sulfur, or oxygen, and a 5-membered heterocyclyl ring where one or more carbon atoms are replaced by nitrogen or sulfur; R3 is hydrogen, (C1-C8) alkyl, (C2-C8) alkenyl, heterocyclyl, aryl or heteroaryl; A is C = C; R4 is hydrogen, halogen, hydroxyl, an optionally substituted (C1-C3) alkyl or cyano; R5 is a group -L-R7, where R7 is hydrogen or an optionally substituted group selected from linear (C1-C8) alkyl, (C3-C8) cycloalkyl and aryl; and L is -CON (Y) -, -NHCO-, -SO2N (Y) -, -NHSO2-, -NHCOCH2-, -CH2CONH-, where Y is hydrogen or, taken together with the nitrogen atom to which they are attached , Y and R7 can form an optionally substituted 3-6 membered heterocyclyl, optionally containing an additional heteroatom selected from nitrogen, sulfur or oxygen; or pharmaceutically acceptable salts thereof, with the proviso that if L is -CH2CONH-, then R2 is different from hydrogen, and that a compound where R2 is cycloalkyl (C5) is excluded.