Compounds and methods to inhibit NHE-mediated anti-port in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders

摘要

A compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the following structure (X): ** Formula ** Core (L-NHE) n (X) in which: n is 2; NHE has one of the following structures: ** Formula ** L is a polyalkylene glycol linker; and the nucleus is selected from the group consisting of: ** Formula **