Gastrointestinal tract post-transplant lympho-proliferative disorder after liver transplantation

摘要

To the Editor:Post-transplant lymphoproliferative disorder (PTLD) is a rare and potentially fatal complication occurring after all types of solid organ transplantation.[1] PTLD accounts for 20% of all de novo post-transplant tumors.[2, 3] The most important risk factors for PTLD are prolonged intense immunosuppression and Epstein-Barr virus (EBV)infection.[4] The gastrointestinal (GI) tract is the most frequently involved site (GI-PTLD), the liver allograft itself can also be involved.[5] As clinical manifestations of PTLD may vary, early diagnosis of PTLD is often difficult.[6, 7]Pathology together with appropriate immunohistochemical detection of EBV infection is the gold standard for diagnosing PTLD. The more frequent localization in the GI tract may be explained by the presence of the rich gut-associated lymphoid tissue as well as antigen-presenting cells. This is in contrast to the fact that the normal liver does not contain lymphoid follicles composed of B or T lymphocytes.[8, 9]