IGFBP7 for the diagnosis of diastolic dysfunction

摘要

Method of diagnosis and / or gradation of diastolic dysfunction and / or at least one structural or functional abnormality of the heart associated with diastolic dysfunction in a patient suffering from heart failure, said method comprising the steps of: a) measuring the IGFBP7 level (insulin-like growth factor binding protein 7) in a sample of a patient suffering from heart failure, in which said patient has a reduced ventricular ejection fraction (LVEF) and b) comparison of the level of IGFBP7 measured in a) with a reference level, in which the structural or functional abnormality associated with diastolic dysfunction is selected from the group consisting of an increased E '/ A' ratio, an increased size of the left atrium, a increased left atrial volume index, increased velocity of peak E, reduced velocity of peak A, increased transmittal E / A ratio, p increased E / E 'ratio, systolic peak velocity of the reduced pulmonary vein, increased diastolic peak velocity of the pulmonary vein, systolic / diastolic rate of the reduced pulmonary vein, increased right ventricular surface, increased right ventricular systolic pressure (PSVD), increased right ventricular dilatation, increased size of the right atrium, mitral regurgitation more than mild and tricuspid regurgitation more than mild.