Recombinant microorganism with Productivity Enhanced putrescine putrescine Production procedure, and using the same

摘要

A recombinant microorganism of Corynebacterium glutamicum which has the capacity to produce putrescine,Where The Micro organism has been changed so that a Protein has the Amino Acid Sequence represented by SEQ ID no: 17 or SEQ ID no: 19, or the expression of them,Is modified in the microorganism to weaken or eliminate the activity of the Protein and increase the production of putrescine compared with the activity of the Protein and ProductionOf putrescine in the same Strain of microorganism but not modify,The Activity of the Protein is weakened by 1) a partial or complete Elimination of a polinucleu00f3tido that encodes the Protein, 2) a reduction in the expression of polinucleu00f3tido,3) a modification of the sequence of polinucleu00f3tido on chromosome to weaken the activity of the Protein 4) or a combination thereof.