Immunotherapy of T lymphocytes targeting cyclin A1 against cancer

摘要

An isolated polypeptide capable of eliciting a response of antigen-specific T lymphocytes to human cyclin A1 (CCNA1), said polypeptide being: a polypeptide of no more than 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10 or 9 amino acids of general formula I: NXC, [I] where: (a) X is an amino acid sequence that is: CCNA1 (227-235) FLDRFLSCM [SEQ ID NO: 3], (b) N is an amino end of the polypeptide and consists of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 amino acids that are independently selected from natural and non-natural amino acids; and (c) C is a carboxy terminus of the polypeptide and consists of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 amino acids that are independently selected from natural and unnatural amino acids.