OPTIMIZED EARLY-LATE PROMOTER COMBINED WITH REPEATED VACCINATION FAVORS CYTOTOXIC T CELL RESPONSE AGAINST ANTIGENS IN REPLICATION DEFICIENT RECOMBINANT VIRUS VACCINES

摘要

The present invention relates to a replication deficient recombinant virusencoding at least one antigen and/or antigenicepitope, wherein expression of said antigen and/or antigenic epitope isregulated by a transcriptional control elementcomprising at least two elements driving early expression of said antigenand/or antigenic epitope and the use of said replicationdeficient recombinant virus as medicament or vaccine.