AMORPHOUS MINOCYCLINE BASE AND PROCESS FOR ITS PREPARATION

摘要

The invention provides amorphous minocycline base in which the content of 4- epi minocycline in the amorphous minocycline base is below 1.2% w/w. Also, a process for preparing amorphous minocycline base, which process comprises spray drying a solution of minocycline in an organic solvent. Amorphous minocycline base is usable for example in the preparation of crystalline minocycline base.