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IN VITRO ARTIFICIAL LYMPH NODE FOR SENSITIZATION AND EXPANSION OF T CELLS FOR THERAPY AND EPITOPE MAPPING
IN VITRO ARTIFICIAL LYMPH NODE FOR SENSITIZATION AND EXPANSION OF T CELLS FOR THERAPY AND EPITOPE MAPPING
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机译:体外人工淋巴结对T细胞的敏感性和扩增,用于治疗和表位定位
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摘要
HER2+ invasive breast cancer (IBC) patients with residual disease following neoadjuvant chemotherapy have an anti-HER2 Type 1 T helper (Th1) cell immune deficit and a significant risk of recurrent disease. It has been shown that anti-HER2 CD4+ T-cell responses incrementally decrease along the breast cancer continuum - a robust response in healthy donors and patients with benign disease, a depressed response in patients with HER2+ ductal carcinoma in situ, and a nearly absent response in patients with HER2+ IBC. This invention relates to a method of creating a microenvironment for culture expansion of T cells. The expanded T cells can be used for a variety of therapeutic and research purposes.
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