MATERIALS AND METHODS FOR MEASURING THE AMYLOID CASCADE BY WATER PROTON RELAXATION AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF AMYLOID DISEASES

摘要

Methods and assays of determining the interaction of a test molecule with amyloid forming biomolecule using water proton relaxation are provided. The methods and assays can measure the changes in water proton relaxation as a result of the interaction of a test molecule with an amyloid forming biomolecule. Aspects of the invention use detection agents capable of interacting with amyloid forming biomolecules; interaction with the detection agent causes a change in the water proton relaxation. The methods and assays are also amenable to high through put screening of molecules that interact with amyloid forming biomolecules.