C(SP3)-C(SP2) CROSS-COUPLING REACTION OF ORGANOZINC REAGENTS AND HETEROCYCLIC (PSEUDO)HALIDES

摘要

Provided is a method of synthesizing a C(sp³)-C(sp²) cross-coupled compound comprising reacting a C(sp³) coupling partner with a C(sp²) coupling partner, a catalyst, and a solvent; wherein the C(sp³) coupling partner comprises an organic zinc reagent; and wherein the C(sp²) coupling partner comprises a heterocyclic halide or a heterocyclic pseudo halide. The method further comprises synthesis of the organic zinc reagent, wherein the synthesis comprises reacting a zinc powder with an acid, filtering, washing, and drying to obtain an activated zinc powder; and reacting the activated zinc powder with a metal iodide catalyst and a second solvent and heating for a predetermined time to obtain the organic zinc reagent.