Methods of reducing or preventing intimal damage caused by mechanical stimulation of endothelial cells

摘要

Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1- TRPM4 channel that is upregulated upon the mechanical stimulation.