Multiplex biomarker for use in evaluation of state of accumulation of amyloid ß in brain, and analysis method for said evaluation

摘要

Provided are: a biomarker which makes it possible to evaluate the state of accumulation of Aβ in brain by employing, as measures, Aβ and an Aβ-like peptide both derived from an amyloid precursor protein (APP) contained in a biological sample; and an analysis method for the evaluation. A marker for evaluating the state of accumulation of Aβ in brain, said marker employing a combination of at least two ratios independently selected from the group consisting of: a ratio of the level of Aβ1-39 (SEQ ID NO: 1) to the level of Aβ1-42 (SEQ ID NO: 3) in a biological sample, i.e., Aβ1-39/Aβ1-42; a ratio of the level of Aβ1-40 (SEQ ID NO: 2) to the level of Aβ1-42 (SEQ ID NO: 3) in the biological sample, i.e., Aβ1-40/Aβ1-42; and a ratio of the level of APP669-711 (SEQ ID NO: 4) to the level of Aβ1-42 (SEQ ID NO: 3) in the biological sample, i.e., APP669-711/Aβ1-42.