IL-21 (HETERODIMERIC FC-FUSED IL-21) FUSED TO IMMUNOGLOBULIN HEAVY CHAIN CONSTANT REGION HETERODIMER (HETERODIMERIC FC), AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

摘要

The present invention relates to: a heterodimer fusion protein (heterodimeric Fc-fused protein) containing first and second Fc regions of an immunoglobulin heavy chain constant region pair and in which IL-21 is bound to the N-terminus and/or C-terminus of the first and/or second Fc region(s), and characterized in that CH3 domains of the first and second Fc regions are modified such that the formation of a heterodimer can be promoted; and a pharmaceutical composition containing the heterodimeric Fc-fused protein. When the immunoglobulin heavy chain constant region heterodimeric Fc-fused protein according to the present invention is used, the in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein can be remarkably increased.