METHOD FOR CONSTRUCTING CONGENITAL IMMUNODEFICIENCY GENE THERAPY VECTOR AND USE THEREOF

摘要

Disclosed are a recombinant lentiviral vector expressing the IL2RG gene, and the preparation thereof, wherein the vector is a self-inactivated third-generation lentiviral vector SIN, and the sequence of the IL2RG gene is as shown in SEQ ID NO: 1. Provided are a method for preparing the vector and the use of the vector in the preparation of a drug for treating primary immunodeficiency diseases.