METHODS AND COMPOSITIONS FOR TREATING MULTIDRUG-RESISTANT CANCER

摘要

#$%^&*AU2018101071A420180913.pdf#####ABSTRACT A method of treating a subject suffering from a multidrug-resistant cancer comprising the step of administering an effective amount of a compound of Formula (1) or its pharmaceutically acceptable salt or solvate to the subject. A method of potentiating the 5 activity of a chemotherapeutic compound in multidrug-resistant cancer cells comprising contacting the multidrug-resistant cancer cells with a compound of Formula (1) or its pharmaceutically acceptable salt or solvate and the chemotherapeutic compound. Also, a pharmaceutical composition comprising a compound of Formula (1) or its pharmaceutically acceptable salt or solvate and the chemotherapeutic compound. 10 Fig. for the Abstract: Fig. 4b 14/16 TXT(1.4tM) - - + + Rg5(gM) -0 8 8 4 2 Fig. 4a lcow A2780/T tII 753 ,80 m 1 E 11~i 27 4 CD ----- a -3. 2 3 4 5 6 TXT(LZpAM)- + - t + + RG5(izM) - 0 8 8 4 2 Fig. 4b