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EphA5- AND GRP78 BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES

机译：EphA5-和GRP78结合抗体及其用于噬菌体显示的可及重组靶向抗体的选择

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摘要

Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.

机译：提供了分离的或重组的Eph A5或GRP78靶向抗体。在一些情况下，实施方案的抗体可以用于人类疾病，例如癌症的检测，诊断和/或治疗。还提供了一种使用体外和体内方法的组合快速鉴定用于治疗癌症的抗体或抗体片段的方法。 展开▼

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公开/公告号WO2018057703A1

专利类型

公开/公告日2018-03-29

原文格式PDF

申请/专利权人 STC.UNM;LOS ALAMOS NATIONAL SECURITY LLC;
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申请/专利号WO2017US52661

发明设计人 PASQUALINI RENATA;ARAP WADIH;STAQUICINI FERNANDA IAMASSAKI;FERRARA FORTUNATO;DANGELO SARA;BRADBURY ANDREW R. M.;
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申请日2017-09-21

分类号C07K16/28;C12N15/13;C12N15/63;A61K39/395;A61P35;

国家 WO

入库时间 2022-08-21 12:44:46

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3. EphA5- AND GRP78 BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES [P] . 美国专利： US2019202922A1 . 2019-07-04

机译： EphA5-和GRP78结合抗体及其用于噬菌体显示的可及重组靶向抗体的选择

4. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A8 . 2018-06-26

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒

5. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A2 . 2018-01-23

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒

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