SWIPE FOR DETERMINING ANALYTES BY MASS-SPECTROMETRY USING LATENT VAPORIZATION REAGENTS AND METHOD FOR USING SAID SWIPE

摘要

Methods and reagents are disclosed for improved detection of inorganic oxidizers, such as but not limited to chlorates, perchlorates, permanganates, dichromates, and osmium tetraoxides. In one aspect of the invention, latent acid-generating reagents are employed that are chemically stable at room temperature but undergo an acidic transformation when exposed to an elevated temperature or radiation. The latent reagent can be activated by heat or radiation (e.g., UV radiation). The resulting acidic reagent can then transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of the target analyte, forming an acid (i.e., chloric acid, perchloric acid) that is more easily vaporized and, hence, more easily detected. In another aspect of the invention, heat-sensitive inorganic salts and/or photosensitive onium salts are disclosed as reagents to carry out this method. In various embodiments, these reagents can be embedded in a swipe or other substrate, infused onto the swipe or sample via nebulizer, or otherwise deployed in a desorption chamber of an ion mobility spectrometer or similar detector.