PH-SENSITIVE AXIALLY-SUBSTITUTED SILICON PHTHALOCYANINE COMPLEX, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF

摘要

The present invention relates to a pH-sensitive ketal-linked cholesterol-silicon phthalocyanine complex, a preparation method therefor and medical application thereof, and in particular, to a silicon phthalocyanine complex represented by a general formula (I), a preparation method therefor, a pharmaceutical composition containing the complex, and use thereof as a photosensitizer, especially use in treating cancers, wherein substituents in the general formula (I) have the same definitions as those in the description. Due to the presence of cholesterol groups, the series of complexes are hardly taken by tumor cells and normal cells; however, in a tumor tissue cell external subacid environment, ketal linkage undergoes hydrolysis reaction, and hydrolysis derivatives of silicon phthalocyanine can be easily taken by cancer cells, show extremely high photosensitivity, and can be prepared into tumor cell external subacid environment targeted photosensitive drug.