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NEURONAL SURVIVAL AND AXONAL REGENERATION THROUGH INCREASING MITOCHONDRIAL MOTILITY
NEURONAL SURVIVAL AND AXONAL REGENERATION THROUGH INCREASING MITOCHONDRIAL MOTILITY
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机译:通过增加线粒体活动性促进神经元存活和轴突再生
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摘要
Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.
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