POLYAMINE COMPOUNDS TARGETING THE EFFLUX PUMPS OF MULTI-DRUG RESISTANT BACTERIAL PATHOGENS AND METHODS OF USING THE SAME

摘要

Disclosed herein are efflux pump inhibitors and pharmaceutical compositions comprising the same. The efflux pump inhibitors may be used in methods of preventing antibiotic resistance in a subject, and in methods of treating a bacterial infection in a subject. The efflux pump inhibitor may be co-administered with an antibiotic.