COATING SYSTEMS ON PLASTIC SUBSTRATES THAT INHIBIT FREE RADICAL-INDUCED DEGRADATION OF BIOLOGICS IN PRIMARY PACKAGING

摘要

A method for preventing or reducing reaction of radiation sterilization-generated free radicals and/or byproducts thereof and/or oxygen with contents of a primary vessel is provided. A radiation sterilized primary plastic vessel contains contents prone to degradation by free radicals and/or byproducts thereof and/or oxygen. The vessel has a coating set deposited on an inner wall. The coating set is effective to protect the contents from degradation by radiation sterilization-generated free radicals and/or byproducts thereof and/or oxygen located in the plastic of the vessel and/or on the inner wall.