SUBSTITUTED 2-METHYLIDENE-5-(PHENYLAMINO)-2,3-DIHYDROTHIOPHEN-3-ONES FOR TREATMENT OF LEUKEMIAS WITH TRANSLOCATIONS OF THE MLL GENE AND OTHER ONCOLOGICAL DISEASES

摘要

The invention relates to the chemistry of organic compounds, pharmacology and medicine, and concerns the prevention and/or treatment of hyperproliferative diseases associated with the malignant transformation of cells expressing the enzyme carboxylesterase hCE1, and specifically, acute leukemias with translocations of the MLL gene, hepatocellular carcinomas, and pulmonary adenocarcinomas. For this purpose, compounds of general formula (I), general formula (II), or general formula (III) are proposed in which R1, R2, A, B, and Q have values indicated in the description. The invention also relates to pharmaceutical compositions containing the indicated compounds, as well as to the use of the above-mentioned compounds for the treatment and/or prevention of hyperproliferative diseases.