SUBSTITUTED 2-METHYLIDEN-5-(PHENYLAMINO)-2,3-DIHYDROTIOPHEN-3-ONE FOR TREATMENT OF LEUKEMIAS WITH TRANSLOCATIONS OF MLL-GENE AND OTHER ONCOLOGICAL DISEASES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to compounds of general formula (I), general formula (II) or general formula (III): formula (I); formula (II); formula (III), where R¹, R² are independently selected and represent -H, substituted or unsubstituted -C₁-C₆-alkyl, the substituents R¹ and R² together with the carbon atom to which they are attached, can form a substituted or unsubstituted -C₃-C₁₂-cycloalkyl; A is independently selected and is: or ;the asterisk indicates the attaching place of substituents; B is selected independently and is: the asterisk indicates the attaching place of substituents; each substituent R^k is independently selected and represents -H, halogen; Q is independently selected and represents -H, -C(=O)-R^L; R^L is independently selected and represents a substituted or unsubstituted -C₁-C₆-alkyl (the values of the remaining radicals are presented in paragraph 1 of the claims).;EFFECT: formula is proposed for the treatment of hyperproliferative diseases associated with malignant transformation of cells expressing the carboxyl esterase hCE1 enzyme, in particular acute leukemias with MLL gene translocations, hepatocellular carcinomas and lung adenocarcinomas.;11 cl, 7 dwg, 12 tbl, 96 ex