SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND APOPTOSIS-INDUCING MOLECULAR THERAPEUTICS

摘要

The invention provides compositions and methods for treating cancers comprising administering a combination of antineoplastic agents, wherein the combination comprises apoptosis-inducing molecular therapeutics and one or more nucleic acid molecules capable of down-regulating expression of at least one splice variant of the IG20 gene, and wherein not ail splice variants of the IG20 gene are down-regulated. In an embodiment, the splice variant of the IG20 gene is a MADD splice variant and the nucleic acid molecules are siRNA, shRNA and antisense oligonucleotides which comprise a nucleic acid sequence complementary to a nucleic acid sequence of exon 13L of the MADD splice variant or to an mRNA transcript of exon 13L of the MADD spiice variant. The invention encompasses methods of treating cancers which include combination therapy with nucleic acid molecules capable of down-regulating the expression of the at ieast one splice variant of the IG20 gene, and apoptosis-inducing molecular therapeutics.