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Novel compound for promoting osteoblast differentiation and inhibiting adipocyte differentiation preparation method thereof and its use

机译:促进成骨细胞分化并抑制脂肪细胞分化的新型化合物及其制备方法和用途

摘要

The present invention relates to a compound for suppressing adipocytic differentiation while promoting osteoblast differentiation and a manufacturing method thereof. The compound is capable of increasing the expression of ALP which is a gene associated with osteoblast differentiation, controlling the expression of PPAR, aP2, and CD36 which are genes associated with adipocytic differentiation, increasing the bone density (BMD) of an osteoporotic animal model with ovariectomy, and reducing the number of adipocytes in bone marrow, thereby being used as an effective component for medicines or healthy functional food for bone metabolism diseases or obesity.
机译:本发明涉及在促进成骨细胞分化的同时抑制脂肪细胞分化的化合物及其制造方法。该化合物能够增加与成骨细胞分化相关的基因ALP的表达,控制与脂肪细胞分化相关的基因PPAR,aP2和CD36的表达,并增加骨质疏松动物模型的骨密度(BMD)。卵巢切除术,减少骨髓中的脂肪细胞数量,从而被用作药物或用于骨骼代谢疾病或肥胖症的健康功能性食品的有效成分。

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