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Compound promoting osteoblast differentiation and inhibiting adipocyte differentiation, preparation method thereof and application thereof
Compound promoting osteoblast differentiation and inhibiting adipocyte differentiation, preparation method thereof and application thereof
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机译:促进成骨细胞分化并抑制脂肪细胞分化的化合物,其制备方法和应用
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摘要
The present disclosure relates to a compound having the activity of promoting osteoblast differentiation and inhibiting adipocyte differentiation and a preparation method thereof. The novel compound of the present disclosure increases the expression of the gene ALP involved in the differentiation of osteoblasts, regulates expression of the genes PPARγ, aP2 and CD36 involved in the differentiation of adipocytes, increases bone mineral density (BMD) in an ovariectomized osteoporosis animal model and decreases adipocytes in the bone marrow. Therefore, it can be used as an active ingredient of a medication or a health functional food useful for metabolic bone disease or obesity.
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