6 134- 134-Oxadiazole Amide Derivative Compounds as Histone Deacetylase 6 Inhibitor and the Pharmaceutical Composition Comprising the same

摘要

The present invention relates to a novel compound having the activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for the production of a therapeutic drug, a pharmaceutical composition containing the same And a method of treating the same, and a method for producing the same. The novel compounds, their optical isomers or pharmaceutically acceptable salts thereof according to the present invention have the activity of inhibiting histone deacetylase 6 (HDAC6) and are useful in the treatment of infectious diseases, neoplasm, endocrine, Related diseases including diseases, mental and behavioral disorders, neurological diseases, eye and appendage diseases, circulatory diseases, respiratory diseases, gastrointestinal diseases, skin and subcutaneous tissue disorders, musculoskeletal and connective tissue disorders or congenital malformations, It is effective for prevention or treatment.