EXTRACT OF SALICORNIA SPP. COMPRISING SODIUM CHLORIDE AND ISORHAMNETIN CAPABLE OF PREVENTING OR TREATING NON-ALCOHOLIC FATTY LIVER DISEASES

摘要

The present invention relates to an extract of Salicornia SPP., and more specifically, to an extract of Salicornia SPP. comprising sodium chloride and isorhamnetin capable of preventing or treating non-alcoholic fatty liver diseases. The isorhamnetin derived from Salicornia SPP. according to the present invention decreases the expression of representative inflammatory markers in liver cells, iNOS and COX-2 proteins in a concentration-dependent manner, and also increases glutathione synthesis enzymes (GR, GCL) through the activation of a representative cell protective transcription factor that fights oxidative stress, Nrf2, and thus may be used in the prevention and treatment of non-alcoholic fatty liver diseases including hepatic inflammation, liver fibrosis, hepatocirrhosis, and the like.;COPYRIGHT KIPO 2018