PI3K Novel Quinazolinone derivatives as PI3K inhibitors and pharmaceutical composition comprising the same

摘要

The present invention relates to novel quinazolinone derivatives inhibiting PI3K; a method for preparing the derivatives; and a pharmaceutical composition for treating hematologic cancers or liver diseases, comprising the quinazolinone derivatives, wherein the novel quinazolinone derivatives according to the present invention have beneficial effects in the treatment of hematologic cancers or liver diseases. In particular, the quinazolinone derivatives inhibit PI3K with high selectivity compared to that of the conventional anticancer drug of PI3K inhibitors, thereby significantly reducing immunotoxicity, or simultaneously inhibit PI3K and PI3K, thereby enabling the treatment of autoimmune diseases as well as anticancer therapy for blood cancers and the like. Such targeted therapeutic agents can resolve the problem of side effects of the conventional highly toxic anticancer therapy.