PI3K Novel Quinazolinone derivatives as PI3K inhibitors and pharmaceutical composition comprising the same

摘要

The present invention relates to novel quinazolinone derivatives inhibiting PI3K, a method of preparing the quinazolinone derivatives, and a pharmaceutical composition for treatment of hematologic tumor or liver disease comprising the quinazolinone derivatives. According to the present invention, a method of preparing a compound represented by chemical formula 1 comprises the steps of: making a compound represented by chemical formula 2 react with a compound represented by chemical formula 3 to prepare a compound represented by chemical formula 4; deprotecting the compound represented by chemical formula 4 to prepare a compound represented by chemical 5; and making the compound represented by chemical formula 5 react with a compound represented by chemical formula 6 to prepare the compound represented by chemical formula 1. According to the present invention, the novel quinazolinone derivatives have useful effects in treatment of hematologic tumor or liver disease. Particularly, the novel quinazolinone derivatives have high selectivities compared to anticancer drugs of existing PI3Kδ inhibitors, remarkably reduce immunotoxicity by inhibiting PI3Kδ, and enable treatment of autoimmune diseases as well as anticancer treatment of hematologic malignancy or the like by inhibiting PI3Kδ and PI3Kγ at the same time. Such a targeted therapeutic agent has an advantage capable of solving side effect problems of existing highly toxic anticancer treatment.