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Process for the preparation of amidated indolines using rhodium catalyst indoline derivatives using the same and pharmaceutical compositions for preventing or treating cancer comprising the same as an active ingredient
Process for the preparation of amidated indolines using rhodium catalyst indoline derivatives using the same and pharmaceutical compositions for preventing or treating cancer comprising the same as an active ingredient
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机译:使用铑催化剂吲哚啉衍生物制备酰胺化的吲哚啉的方法以及用于预防或治疗癌症的药物组合物
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摘要
The present invention relates to a method for manufacturing an amidated indoline using a rhodium catalyst, a compound using the same and a pharmaceutical composition for cancer prevention or treatment containing the same as an active ingredient. The amidated indoline using the rhodium catalyst according to the present invention is confirmed to have a high cytotoxic effect against prostate adenocarcinoma (LNCaP), endometrial adenocarcinoma (Ishikawa), and ovarian cancer (SKOV3) through an evaluation of anticancer activity so that the amidated indoline is expected to be used as a pharmaceutical composition for cancer prevention or treatment.
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