Process for the preparation of amidated indolines using rhodium catalyst indoline derivatives using the same and pharmaceutical compositions for preventing or treating cancer comprising the same as an active ingredient

摘要

The present invention relates to a process for preparing amidated indolin using a rhodium catalyst, a compound using the same, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The amidated indoline using the rhodium catalyst according to the present invention was found to have a high cytotoxic effect through evaluation of anticancer activity against prostate adenocarcinoma (LNCaP), endometrial adenocarcinoma (Ishikawa), and ovarian cancer (SKOV3) It is expected that the composition can be usefully used as a pharmaceutical composition for prevention or treatment.