- Composition comprising a phenylalanine-chloroquine derivative as an active ingredient for preventing and treating malaria infection

摘要

The present invention relates to a composition, comprising a phenylalanine-chloroquine derivative compound, represented by a general formula (I), with a novel structure or a pharmacologically acceptable salt as an active ingredient, for treating and preventing malaria. As a result of identification of anti-malaria activity through a search (experiment example 1) for an anti-malaria effect in vitro by using a strain of Plasmodium falciparum and an animal test (experiment example 2) using a mouse infected from malaria with respect to phenylalanine-chloroquine derivative compounds with novel structures, the novel compounds have been identified to have excellent anti-malaria activity. Accordingly, an anti-malaria agent comprising a phenylalanine-chloroquine derivative compound with a novel structure or a pharmacologically acceptable salt as an active ingredient is provided.