-2- TRANSGENIC MOUSE EXPRESSING INACTIVATED HUMAN IDURONATE-2-SULPHATASE AND METHOD FOR IMPROVING A HUNTER SYNDROME TREATING AGENT USING SAME

摘要

The present invention relates to a transgenic mouse expressing an inactive human iduronate-2-sulfatase in which cysteine at amino acid position 84 is substituted with threonine. The present invention further relates to a method for improving a therapeutic agent for Hunter syndrome using the same. Specifically, the iduronate-2-sulfatase as therapeutic agent for Hunter syndrome treatment is administered to the transgenic mouse expressing the inactive human iduronate-2-sulfatase in which cysteine at amino acid position 84 was substituted with threonine, immune response to the therapeutic agent, iduronate-2-sulfatase, does not occur. Thus, the transgenic mouse can be useful for finding out immunogenicity factors except the immunogenicity of the protein component of the therapeutic agent.