首页> 外国专利> (5S, 10S) -10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenic acid- (E) -3-carboxyacrylate salt

(5S, 10S) -10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenic acid- (E) -3-carboxyacrylate salt

机译：（5S，10S）-10-苄基-16-甲基-11,14,18-三氧-15,17,19-三氧-2,7,8-三硫-12-氮杂二酸-（E）-3-羧基丙烯酸酯盐

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摘要

(5S, 10S) -10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia- (E) -3-carboxyacrylate salt of the following formula: RTI ID = 0.0 Where X ^- is fumarate. The process comprises the following successive main steps: kinetic resolution to form the desired product of formula ( I ), formation of disulfide compounds, peptide coupling, and anion exchange reaction.

机译：下式的（5S，10S）-10-苄基-16-甲基-11,14,18-三氧-15,17,19-三氧-2,7,8-三硫-（E）-3-羧基丙烯酸盐：其中X ^{-是富马酸酯。该方法包括以下连续的主要步骤：动力学拆分以形成所需的式（ I ）产物，二硫化物化合物的形成，肽偶联和阴离子交换反应。} 展开▼

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公开/公告号KR20180095507A

专利类型

公开/公告日2018-08-27

原文格式PDF

申请/专利权人 파마리드스;
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申请/专利号KR20187013628

发明设计人 포라스 허브;리페브르 로익;짜오 신준;감베로니 루카;데 로사 사브리나;베라르디 로사리오;
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申请日2016-10-14

分类号C07C319/22;C07C319/24;C07C323/60;C07C327/32;

国家 KR

入库时间 2022-08-21 12:39:18

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1. 制备(5S,10S)-10-苄基-16-甲基-11,14,18-三氧代-15,17,19-三氧杂-2,7,8-三硫杂-12-氮杂二十一烷-5-铵(E)-3-羧基丙烯酸盐的工业工艺 [P] . 中国专利： CN108430968B . 2021.01.05

2. 制备(5S,10S)-10-苄基-16-甲基-11,14,18-三氧代-15,17,19-三氧杂-2,7,8-三硫杂-12-氮杂二十一烷-5-铵(E)-3-羧基丙烯酸盐的工业工艺 [P] . 中国专利： CN108430968A . 2018-08-21

3. Industrial process for the preparation of (5s, 10s) -10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (e) -3-carboxyacrylate salt [P] . DK3362433T3 . 2020-09-21

机译：制备（5s，10s）-10-苄基-16-甲基-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-的工业方法（e）-3-羧基丙烯酸铵盐

4. Industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt [P] . AU2016336891B2 . 2020-07-09

机译：制备（5S，10S）-10-苄基-16-甲基-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-的工业方法（E）-3-羧基丙烯酸铝盐

5. Industrial process for the preparation of (5s,10s)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (e)-3-carboxyacrylate salt [P] . IL258663A . 2020-08-31

机译：制备（5s，10s）-10-苄基-16-甲基-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-的工业方法（e）-3-羧基丙烯酸铵盐

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