Method for Preparing Dendritic Cell With Increased Expression of Specific Genes And Composition For Preventing Or Treating Autoimmune Diseases Comprising Semi-Mature Dendritic Cell Prepared By The Same

摘要

The present invention provides a method for treating an autoimmune disease, particularly rheumatoid arthritis, by treating immature dendritic cells with autoantigen, cytokine and PGE2 to treat NR4A2 and / or UBASH3B protein, The present invention relates to a method for producing a semi-mature dendritic cell in which expression of a gene encoding a protein is increased more than two-fold. The present invention also relates to a cell therapy agent for treating or preventing an autoimmune disease, which comprises the semi-mature dendritic cell as an active ingredient. According to the present invention, the treatment efficacy of a patient with rheumatoid arthritis, which has reactivity to the same autoantigen as that of the autoantigen treated in semi-mature dendritic cells, can be enhanced to enable cell therapy.