首页> 外国专利> PINK1 Composition for diagnosing neuropathic pain comprising PTEN-induced putative kinase 1

PINK1 Composition for diagnosing neuropathic pain comprising PTEN-induced putative kinase 1

机译:用于诊断神经性疼痛的PINK1组合物,其包含PTEN诱导的推定激酶1

摘要

The present invention relates to a biomarker composition including PINK1 for diagnosing neuropathic pain, a composition or a kit including the same containing a medicine for measuring mRNA expression of PINK1 or protein activity thereof and a method of screening a neuropathic pain medicine. PINK1 of the present invention is expressed especially in GABA type nerve and associated closely with mitophagy in mitochondria. Moreover, since the expression of the PINK1 significantly increases in a patient with neuropathic pain, as compared to healthy people, the PINK1 is used as a biomarker for diagnosing neuropathic pain or is used as a composition or kit for diagnosing neuropathic pain by using a medicine for measuring mRNA expression or protein activity. Furthermore, the present invention is able to be used in various medical and biological fields as a method of screening a neuropathic pain medicine by measuring mRNA expression of PINK1 or protein activity thereof.
机译:本发明涉及包含用于诊断神经性疼痛的PINK1的生物标志物组合物,包含用于测量PINK1的mRNA表达或其蛋白质活性的药物的组合物或包含该药物的组合物和试剂盒,以及筛选神经性疼痛药物的方法。本发明的PINK1尤其在GABA型神经中表达,并且与线粒体的线粒体吞噬密切相关。而且,由于PINK1的表达在患有神经性疼痛的患者中显着增加,因此与健康人相比,PINK1被用作诊断神经性疼痛的生物标志物,或者用作通过药物诊断神经性疼痛的组合物或试剂盒。用于测量mRNA表达或蛋白质活性。此外,本发明作为通过测量PINK1的mRNA表达或其蛋白活性来筛选神经性止痛药的方法,能够用于各种医学和生物学领域。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号