Cosmetic composition for skin whitening containing Campylotropis hirtella extract with inhibitory activity of tyrosinase and melanin formation

摘要

The invention kaempilro trophy's Nevsehir telra (Campylotropishirtella) extract, or a cosmetic composition for skin whitening comprising the compound or a pharmaceutically acceptable salt thereof separated therefrom as an active ingredient having a tyrosinase and melanin synthesis inhibitory activity when the tie Specifically, the methanol extract of Campylotrophis hirtila root inhibited tyrosinase activity in a concentration-dependent manner. It was confirmed that the IC ₅₀ value was 20 μg / ml, and the compound isolated from the fraction of the extract Neorauflavane has an IC ₅₀ value of 30 nM for inhibition of monophenolase activity, which is 100 times more active than albutin and kojic acid, which are currently used as reference materials , And the IC ₅₀ value for the inhibition of the activity of dephenolase was 500 nM, and another compound The IC ₅₀ values for 3'-geranyl-5,7,2 ', 4'-tetrahydroxyisoflavanone were confirmed to be 2.9 μM and 128 μM for monophenolase and diphenolase, respectively. Also, the concentration of Campylo tropis hirtella extract In particular, Neorauflavane and 3'-geranyl-5,7,2 ', 4'-tetrahydroxyisoflavanone inhibited melanin synthesis, confirming that the I _C50 for inhibition of melanin synthesis was 13 μM and 42.3 μM, respectively, Neerauflavane and 3'-geranyl-5,7,2 ', 4'-tetrahydroxyisoflavanone isolated from Tella extract remarkably inhibit tyrosinase, monophenolase and diphenolase, and melanin synthesis, The composition containing the active ingredient is a cosmetic composition for skin whitening, and can be usefully used as a functional material for skin whitening and lightening.