Biomarker Composition for Diagnosing Nanoparticles Neurotoxicity by Increasing Cytoplasmic Inclusion Bodies in vitro

摘要

The present invention relates to a biomarker composition for the diagnosis of neurotoxicity of nanoparticles, wherein nanoparticles such as MNPs @ SiO ₂ (RITC) increase intracellular polyamine metabolites, such as putrescine, and spermidine and spermine In addition, the expression of ODC1, SAT1, PAOX and SRM1, which are related to the metabolism of polyamines, is increased to increase inclusion body formation and cause nerve impairment. In addition, nanoparticles formed by intracellular aggregation by nanoparticles As an indicator for determining toxicity, a gene associated with polyamine metabolites and polyamine metabolism can be used to provide a nano-neurotoxic biomarker.