Pharmaceutical Composition for Prevention or Treatment of Brain Cancer Comprising Robarstin and Combination Therapy in the Treatment of Brain Cancer Using the Same

摘要

The present invention relates to novel uses of natural metabolite rovastine, and more particularly to the use of rovastine or a pharmaceutically acceptable salt thereof for the prophylactic or therapeutic use of brain cancer and for the treatment of brain cancer with temozolomide / RTI Lobarstin, a compound according to the present invention, has been shown to exhibit cytotoxicity upon treatment with a temozolomide resistant cancer cell line, and thus can be prepared as a drug capable of overcoming anticancer drug resistance. It has been shown that apoptosis is promoted in the combination treatment with mide, so that it is also possible to develop a therapeutic agent for combination with existing treatment.