PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF BRAIN CANCER COMPRISING ROBARSTIN AND COMBINATION THERAPY IN THE TREATMENT OF BRAIN CANCER USING THE SAME

摘要

The present invention relates to a novel use of lobarstin which is a metabolite derived from a natural substance and, more specifically, to a use of a composition comprising lobarstin or a pharmaceutically acceptable salt thereof for preventing or treating brain cancer, and to a use thereof in combined therapy, in conjunction with temozolomide, for treating brain cancer. Since it has been confirmed that cell cytotoxicity is exhibited when a temozolomide resistant cancer cell line is treated solely with lobarstin, which is a compound according to the present invention, the present invention can be prepared as a drug for overcoming anticancer drug resistance. Further, it has been confirmed that cell death is promoted during combined treatment using lobarstin and temozolomide, which is a cancer drug for a standard therapy, and thus, it is possible to develop the present invention as a drug for combined therapy in addition to a conventional therapy.