H9 H5 RECOMBINANT INFLUENZA VIRUS TO FORM CROSS-PROTECTION AGAINST MULTIPLE SUBTYPES H9 AND H5 OF INFLUENZA VIRUSES AND VACCINE COMPRISING THE SAME

摘要

The present invention relates to a novel influenza virus effective for cross-reacting with influenza viruses of different subtypes H9 and H5, a vaccine containing the same as an active ingredient, and a method for preventing or treating an influenza virus infection disease / RTI The recombinant influenza virus of the present invention includes a chimeric hemagglutinin gene prepared by fusing the hemagglutinin HA1 region and the HA2 region derived from two different subtypes, And exhibits a cross-reactive effect against a virus having a clade, it can be very usefully used as a virus vaccine having a wide range of neutralizing antibody effects.