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METHOD OF PURIFYING NEUTRAL OLIGOSACCHARIDE OF BREAST MILK USING CHROMATOGRAPHY WITH SIMULATED MOTION OF STRAIGHT PHASE
METHOD OF PURIFYING NEUTRAL OLIGOSACCHARIDE OF BREAST MILK USING CHROMATOGRAPHY WITH SIMULATED MOTION OF STRAIGHT PHASE
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机译:模拟直相色谱层析分离纯化母乳中性低聚糖的方法
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摘要
The present application discloses a process for the purification of 2'-fucosyllactose produced by fermentation, enzymatic synthesis or chemical synthesis or combinations thereof. The process uses simulated moving bed (SMB) chromatography which allows the continuous purification of large quantities of 2'-fucosyllactose at high purity. Contrary to the purification currently used in chemical synthesis route of 2'-fucosyllactose, the presented process allows the provision of 2'-fucosyllactose free of noxious chemicals like e.g. trace amounts of heavy metals or organic solvents. 2'-fucosyllactose may be obtained in solid form by spray drying. The provided 2'-fucosyllactose is very well-suited for use in food applications.
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