Activation of hematopoietic progenitor cells by pre-transplantation exposure to death receptor ligands

摘要

The present invention concerns methods for enhancing the engraftment and improving transplantation outcome of hematopoietic stem and progenitor cells by exposure of the cells to ligands of the TNF superfamily prior to transplantation. The invention also provides populations of hematopoietic stem and progenitor cells that were activated according to the method of the invention, for use in transplantation.