METHOD FOR EVALUATING THE RISK OF AN UNFAVORABLE OUTCOME OF DISEASE IN STOMACH CANCER PATIENTS

摘要

FIELD: medicine.SUBSTANCE: invention relates to the field of medicine, specifically to oncology, and relates to a method for determining the degree of risk of an adverse outcome of a disease in patients with gastric cancer. Essence of the method: in the stomach tumor, the total calpain activity is determined, Chymotrypsin-like total proteasome activity, activity of 26S and 20S proteasome pools, content of subunits amount α Σα, content of the LMP7 subunit, content of the LMP2 subunit, content of the PA28β, subunit, content of the Rpt6 subunit, also take into account the age of the patients. Then, the values of the discriminant functions Y1, Y2 are calculated from the equations. At Y1Y2, a low, and at Y1Y2 – high risk of adverse outcome of stomach cancer, in the case when the characteristics of the object presented for recognition satisfy the condition Y1=Y2, recognition is impossible without additional information. Sensitivity of the method is 67 %, the specificity is 96 %.EFFECT: increasing the accuracy of the method.1 cl, 1 tbl, 2 ex