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SOLID DOSAGE FORMS OF ONDANSETRON WITH PROLONGED RELEASE FOR TREATING SYMPTOMS OF NAUSEA, VOMITING AND DIARRHEA
SOLID DOSAGE FORMS OF ONDANSETRON WITH PROLONGED RELEASE FOR TREATING SYMPTOMS OF NAUSEA, VOMITING AND DIARRHEA
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机译:用于治疗恶心,呕吐和腹泻症状的恩丹西酮长时间释放固体剂型
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摘要
A method of treating a patient comprises orally administering a solid oral dosage form comprising a core comprising a non-ionic polymer matrix, a first amount of ondansetron dispersed within the matrix, and a salt dispersed within the matrix, wherein the first amount of ondansetron ranges from about 9 mg to about 28 mg; a first seal coat surrounding the core, wherein the first seal coat is comprised of a non-ionic polymer matrix; and an immediate release drug layer surrounding the first seal coat and comprising a non-ionic polymer and a second amount of ondansetron dispersed therein, wherein the second amount of ondansetron ranges from about 3 mg to about 8 mg, wherein release of ondansetron from the solid oral dosage form provides exposure to ondansetron for a minimum period of 16 hours so as to result in a reduction in frequency of vomiting, nausea, diarrhea, or a combination thereof.
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