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DNA-VACCINE FOR APPLICATION IN PATIENTS WITH PANCREATIC CANCER
DNA-VACCINE FOR APPLICATION IN PATIENTS WITH PANCREATIC CANCER
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机译:DNA疫苗在胰腺癌患者中的应用
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摘要
FIELD: biotechnology.;SUBSTANCE: invention relates to an attenuated mutant Salmonella enterica Serovar Typhi Tu21a strain and a vaccine containing such a strain. The present strain contains, at least, one copy of a recombinant DNA molecule that contains a eukaryotic expression cassette encoding VEGF protein receptors, wherein the VEGF receptor protein is human VEGFR-2, which has an amino acid sequence as set forth in SEQ ID NO: 1 for use as a vaccine in immunotherapy of malignant tumours, where a single dose of the vaccine is 1×109 or less than 1×109 CFU.;EFFECT: inventions allows to obtain necessary immunological and clinical responses at very low doses.;16 cl, 12 dwg, 2 tbl, 7 ex
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机译:减毒突变株肠沙门氏菌血清型伤寒沙门氏菌Tu21a菌株和含有该菌株的疫苗。本菌株至少包含一个拷贝的重组DNA分子拷贝,该拷贝DNA分子包含编码VEGF蛋白受体的真核表达盒,其中VEGF受体蛋白是人VEGFR-2,其具有如SEQ ID NO所示的氨基酸序列。 :1用作恶性肿瘤免疫治疗的疫苗,其中疫苗的单剂量为1×10 9 Sup>或小于1×10 9 Sup> CFU。 :发明允许以非常低的剂量获得必要的免疫学和临床反应。; 16 cl,12 dwg,2 tbl,7 ex
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