METHOD FOR PREDICTION OF RISK OF SEVERE PREECLAMPSIA DEVELOPMENT

摘要

FIELD: medicine.;SUBSTANCE: method involves isolation of DNA from peripheral venous blood, analysis of MMP-8 (rs1320632) gene polymorphism in combination with other predictors of development of this pregnancy pathology. Risk of severe preeclampsia development is predicted according to the equations of linear discriminant function: y₁=-14.767+ 2.914x₁+1.439x₂+0.222x₃+14.345x₄, y₂=-2.228+2.305x₁-0.718x₂+1.888x₃-0.254x₄, where x₁ - is genetic version at the MMP-8 (rs1320632) locus (AA - 1; AG or GG - 0), x₂ is presence of preeclampsia in relatives (1 - yes, 0 - no), x₃ is presence of sexually transmitted diseases (1 - yes, 0 - no), x₄ is presence of gynecological pathologies in the anamnesis (1 - yes, 0 - no), in the event that the value of y₁ is greater than y₂.;EFFECT: effective implementation of therapeutic and preventive measures to prevent pregnancy pathology.;3 ex, 2 dwg