INHIBITORS OF ZINC-DEPENDENT METALLOPROTEINASES (MMP-2 AND MMP-9) IN NUMBER OF BENZOILAMINO (PHENYLSULFONYL)-SUBSTITUTED CYCLIC AMINO ACIDS AS POTENTIAL PHARMACEUTICALS THAT PREVENT POSTINFARCT REMODELLING OF LEFT VENTRICLE

摘要

FIELD: biotechnology.;SUBSTANCE: benzoilamino (phenylsulfonyl)-substituted cyclic amino acids of the general formula where R¹, R², R³, R⁴, R⁵, R⁶, R⁷ may be hydrogens, halogen atoms, (C₁-C₄)-alkyl groups, nitro groups; "n" can be 1-3, and their physiologically acceptable salts which are inhibitors of zinc-dependent metalloproteinases (MMP-2 and MMP-9). Also a method for preparation of compounds of formula (1) and a method for treating by remodelling of the left ventricle of the heart in the peracute phase of myocardial infarction using compounds of the formula (1) are provided.;EFFECT: increased efficiency of treatment.;4 cl, 3 dwg, 2 tbl, 3 ex